2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W1122690
    Vitamin K-d7 1233937-39-7
    Vitamin K-d7 is the deuterium labeled Vitamin K (HY-B2172). Vitamin K, the blood-clotting vitamin, is important for the function of numerous proteins within the body, such as the coagulation factors, osteocalcin and matrix-Gla protein.
    Vitamin K-d7
  • HY-W181626A
    Tiprenolol hydrochloride 13379-87-8 98%
    Tiprenolol hydrochloride is a β-adrenoceptor blocker. Tiprenolol hydrochloride abolished ventricular arrhythmias induced by intravenous epinephrine in dogs receiving halothane inhalation.
    Tiprenolol hydrochloride
  • HY-W195048R
    Tetradecyl sulfate sodium (Standard) 1191-50-0 98%
    Tetradecyl sulfate sodium (Standard) is an analytical standard of tetradecyl sulfate sodium. This product is intended for research and analytical applications. Tetradecyl sulfate sodium is an anionic detergent sclerosant. Tetradecyl sulfate sodium disturbs phospholipid cell membranes, causing membrane solubilization and cell lysis at high concentrations, and creates endothelial cell membrane negative charge to induce coagulation, thrombotic occlusion, fibrosis, and vessel ablation at lower concentrations. Tetradecyl sulfate (sodium) can be used for the research of hemangioma, Kaposi sarcoma, lymphangioma circumscriptum.
    Tetradecyl sulfate sodium (Standard)
  • HY-W267062A
    BI SF3 hydrochloride 1801257-24-8 98%
    BI SF3 hydrochloride is a synthetic intermediate that can be used in the synthesis of quinolinyloxazoles with kallikrein inhibitory activity.
    BI SF3 hydrochloride
  • HY-W278566R
    Saluamine (Standard) 3086-91-7
    Saluamine (Standard) is the analytical standard of Saluamine (HY-W278566). This product is intended for research and analytical applications. Saluamine is an important N-dealkylated metabolite of Furosemide (HY-B0135) that is produced by microbial transformation and bile metabolism.
    Saluamine (Standard)
  • HY-W327449R
    Feruloylputrescine (Standard) 501-13-3 98%
    Feruloylputrescine is an oral active phenolamide found in citrus plants and formed through the decarboxylation of L-Arginine. Feruloylputrescine inhibits monooxygenase (cntA) and reductase (cntB) and trimethylamine production. Feruloylputrescine can be used for cardiovascular diseases research.
    Feruloylputrescine (Standard)
  • HY-W376701R
    Guanadrel (Standard) 40580-59-4 98%
    Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies.
    Guanadrel (Standard)
  • HY-W414915R
    Valsartan methyl ester (Standard) 137863-17-3 98%
    Valsartan (CGP 48933) methyl ester (Standard) is the analytical standard of Valsartan methyl ester (HY-W414915). This product is intended for research and analytical applications. Valsartan methyl ester is the methyl ester derivative of Valsartan (HY-18204). Valsartan is a selective angiotensin II type 1 (AT1) receptor blocker (ARB) with potent antihypertensive and cardioprotective effects. Valsartan competitively binds to AT1 receptors, inhibiting the binding of angiotensin II to AT1 receptors, thereby blocking angiotensin II-mediated vasoconstriction, sodium retention, and myocardial hypertrophy signaling pathways. Valsartan reduces systolic blood pressure in L-NAME-induced hypertensive rats. Valsartan can be used for the study and treatment of arterial hypertension, hypertensive heart disease, and heart failure.
    Valsartan methyl ester (Standard)
  • HY-W755295R
    Mabuterol hydrochloride (Standard) 54240-36-7
    Mabuterol (hydrochloride) (Standard) is the analytical standard of Mabuterol (hydrochloride). This product is intended for research and analytical applications. Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB.
    Mabuterol hydrochloride (Standard)
  • HY-W010950AR
    Flecainide hydrochloride (Standard) 57415-44-8 98%
    Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT).
    Flecainide hydrochloride (Standard)
  • HY-W013812S1
    Ethyl linoleate-d5 1169764-57-1 98%
    Ethyl linoleate-d5 (Linoleic Acid ethyl ester-d5) is deuterium labeled Ethyl linoleate. Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators.
    .
    Ethyl linoleate-d5
  • HY-W014375S3
    DL-Arginine-d7 hydrochloride 98%
    DL-Arginine-d7 hydrochloride is deuterium labeled DL-Arginine hydrochloride (HY-W014375). DL-Arginine ((±)-Arginine) hydrochloride is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells.
    DL-Arginine-d7 hydrochloride
  • HY-W014901S1
    Bisphenol F-13C12 1410794-08-9 98%
    Bisphenol F-13C12 is the 13C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260).
    Bisphenol F-13C12
  • HY-W141978S1
    DL-Lysine-d8 dihydrochloride 284664-87-5 98%
    DL-Lysine-d8 (dihydrochloride) is the deuterium labeled DL-Lysine.
    DL-Lysine-d8 dihydrochloride
  • HY-P0036S
    Octreotide-d8 TFA 98%
    Octreotide-d8 (SMS 201-995-d8) TFA is the deuterium labeled Octreotide TFA. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly.
    Octreotide-d8 TFA
  • HY-124208A
    L-770644 dihydrochloride 182251-68-9 98%
    L-770644 is an orally active, potent and selective agonist of the human β3 adrenergic receptor (EC50 = 13 nM).
    L-770644 dihydrochloride
  • HY-B0627S1
    Metformin-13C2 hydrochloride 98%
    Metformin-13C2 (1,1-Dimethylbiguanide-13C2) hydrochloride is the 13C-labeled Metformin hydrochloride (HY-17471A). Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.
    Metformin-13C2 hydrochloride
  • HY-17421A
    Tenatoprazole sodium 335299-59-7 98%
    Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H+/K+-ATPase with an IC50 of 6.2 μM.
    Tenatoprazole sodium
  • HY-P0316
    TP508 121341-81-9 98%
    TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues.
    TP508
  • HY-101628
    VEGFR-2-IN-9 408502-06-7 98%
    VEGFR-2-IN-9 (KDR-in-4) is a potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor with an IC50 of 7 nM.
    VEGFR-2-IN-9
Cat. No. Product Name / Synonyms Application Reactivity